History of the Hypoxia Lab

History
of the
Hypoxia Lab

Founded by John W. Severinghaus, MD, in 1958, the UCSF Hypoxia Research Laboratory is a leading center for the study of the effects of hypoxia on humans. The laboratory has focused on oxygen transport, oxygen measurement, and high-altitude physiology for more than 40 years. Studies done in San Francisco and at the University of California’s White Mountain Research Station represent some of the most important studies ever done on human adaptation to high altitude. We continue this interest in studies on control of breathing and adaptation to hypoxia in humans.

A major current activity of the laboratory is evaluation of the accuracy of pulse oximetry. We have a continuing interest in pulse oximeter development and provide accuracy testing of pulse oximeters and related devices for industry. We are a completely independent university-based testing facility with no ties to pulse oximeter manufacturers.

Hypoxia Lab
Physicians
and Staff

John Severinghaus

John W. Severinghaus, M.D.

Professor Emeritus
Department of Anesthesia and Perioperative Care
University of California, San Francisco

Inventor of modern blood gas analysis, inventor of the carbon dioxide electrode 40 years at UCSF, > 200 peer reviewed publications in areas of gas exchange, gas transport. Clinical monitoring technology, human adaptation to high altitude environments Dr. Severinghaus began studying pulse oximeter in 1985, and developed the protocols used for testing pulse oximeters in this lab, and in many other labs throughout the world. Dr. Severinghaus continues to offer his advice and support to the laboratory.

Phil Bickler

Philip E. Bickler, Ph.D., M.D.

Professor
Department of Anesthesia and Perioperative Care
University of California, San Francisco
Director of Hypoxia Research Laboratory and Neuroscience laboratories

Dr. Bickler joined Dr. Severinghaus as a research fellow in 1986 and has directed the laboratory since Dr. Severinghaus’ retirement in the early 1990’s. In addition to the hypoxia laboratory for clinical studies, Dr. Bickler directs a basic science laboratory that is involved in studying how neurons adapt to oxygen deprivation. He has published over 80 peer reviewed studies. See the Bickler lab website. See the Bickler lab website.

John Feiner

John R. Feiner, M.D.

Professor
Department of Anesthesia and Perioperative Care
University of California, San Francisco

Dr. Feiner joined Dr. Severinghaus in the lab in 1992 and has been participating in the study of pulse oximeters since then. Dr. Feiner is reponsible for data acquisition programming and data analysis.

Dr. Feiner is also Director of Liver Transplant Anesthesia.

Mark Rollins

Mark Rollins, M.D., Ph.D.

Assistant Professor
Department of Anesthesia and Perioperative Care
University of California, San Francisco

Dr. Rollins joined the Hypoxia Research Lab in 2006 and has been participating in the study of pulse oximeters since then. Dr. Rollins reasearch is focused on the importance of oxygen in wound healing.

Jeffrey Sall

Jeff Sall, M.D., Ph.D.

Assistant Professor
Department of Anesthesia and Perioperative Care
University of California, San Francisco

Dr. Sall joined the Hypoxia Research Lab in 2005 and has been participating in the study of pulse oximeters since then. Dr. Sall’s basic science research concerns the effects of anesthetics on neural stem cells.

J-Lucero-1

Helge Eilers, MD

Associate Professor of Clinical Anesthesia

Dr. Eilers has been a part of the Hypoxia Lab research team for the past 4 years. In addition to being a part of our team, Dr Eilers is involved in a number of research projects focused on the advancement of our understanding of the molecular mechanisms responsible for the transduction of painful stimuli in peripheral nociceptive neurons. His main effort is currently directed at investigating the effects of general anesthetics in peripheral nociceptors. Irritant anesthetics such as isoflurane have been shown to activate sensory neurons and may contribute to the severity of postoperative pain.

J-Lucero-1

Jennifer Lucero, MD

Assistant Professor
Division of Obstetric Anesthesia
Department of Anesthesia & Perioperative Care
Department of Obstetrics, Gynecology & Reproductive Sciences

Dr. Lucero joined the lab in 2012 after completing her research fellowship, and has been participating in the study of pulse oximeters since that time. In addition, Dr. Lucero’s research interests are in Women’s Health related areas and she is currently conducting translational research in preeclampsia.

Paul Au

Paul Au, B.S.

Clinical Coordinator & Lab Technician

Paul joined the Hypoxia Research Lab in 2009, transitioning from basic science research to the role of Clinical Research Coordinator. He received his Bachelors of Science from UC Davis in 2005. His continued education at San Francisco State’s College of Extended Learning Clinical Trials Design and Management certificate program has given him the knowledge to coordinate the many active protocols the Hypoxia Research Lab has. Paul’s main roles in the lab are coordinating study subjects, assisting during studies, and maintaining all regulatory documents necessary for clinical research in accordance with good clinical practices. For more information on scheduling, please email him at aupaul@anesthesia.ucsf.edu.

San Francisco
Amenities

Our facility is located in world-famous San Francisco, rich with diversity, history, and attractions to suit any interest. While here, take advantage of many activities as well as some of the best restaurants in the country. We are also a short distance from the famous Napa Valley wine country.

Attactions and sites

Accomodations

Restaurants

A Few
of Our
Clients

Massimo Coorporation Covidien Charmcarepacific medecosiemensrenu medicalconmed logonihon kohdendixtal novametrixSterilmed logo

Hypoxia Lab
Publications

Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers.

Bickler PE, Feiner JR, Rollins MD., 2013 Oct;117(4):813-23.

Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers.

Dubowitz G1, Breyer K, Lipnick M, Sall JW, Feiner J, Ikeda K, MacLeod DB, Bickler PE.,Anaesthesia. 2013 Dec;68(12):1220-3

Accuracy of Carboxyhemoglobin Detection by Pulse CO-Oximetry During Hypoxemia.

Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler PE.,Anesth Analg. 2013 Mar 11. [Epub ahead of print]

Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia.

Feiner JR, Bickler PE., Anesth Analg. 2010 Nov;111(5):1160-7., Epub 2010 Sep 14.

Accuracy of Methemoglobin Detection by Pulse CO-Oximetry During Hypoxia.

Feiner JR, Bickler PE, Mannheimer PD. Anesth Analg. . [Epub ahead of print]

Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender.

Feiner JR, Severinghaus JW, Bickler PE. Anesth Analg. 2007 Dec;105(6 Suppl):S18-23, tables of contents.

Effects of skin pigmentation on pulse oximeter accuracy at low saturation.

Bickler PE, Feiner JR, Severinghaus JW. Anesthesiology. 2005 Apr;102(4):715-9

Pulse oximetry in the diagnosis of acute mountain sickness.

O'Connor T, Dubowitz G, Bickler PE. High Alt Med Biol. 2004 Fall;5(3):341-8.

Falsely low pulse oximetry values in patients receiving docetaxel (Taxotere).

Paige M, Bickler PE. Anesth Analg. 2004 Aug;99(2):622-3. No abstract available

Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema.

Podolsky A, Eldridge MW, Richardson RS, Knight DR, Johnson EC, Hopkins SR, Johnson DH, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Severinghaus JW, Wagner PD. J Appl Physiol. 1996 Aug;81(2):922-32.

Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema.

Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Wagner PD, Severinghaus JW. J Appl Physiol. 1996 Aug;81(2):911-21.

Hypoxic ventilatory response predicts the extent of maximal breath-holds in man.

Feiner JR, Bickler PE, Severinghaus JW. Respir Physiol. 1995 Jun;100(3):213-22

Hemoglobin desaturation after succinylcholine-induced apnea: a study of the recovery of spontaneous ventilation in healthy volunteers.

Heier T, Feiner JR, Lin J, Brown R, Caldwell JE. Anesthesiology. 2001 May;94(5):754-9.

Acute severe isovolemic anemia impairs cognitive function and memory in humans.

Weiskopf RB, Kramer JH, Viele M, Neumann M, Feiner JR, Watson JJ, Hopf HW, Toy P. Anesthesiology. 2000 Jun;92(6):1646-52.